Definition of Unlock

Unlock
Description
Unlock
In-Game Secret Number

Metronome

Unlocked a new item.
Defeat Ultra Greedier as Eden
303
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Lachryphagy

Unlocked a new item.
Collect 10 "tears up" items or pills in one run
378
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Jumper Cables

Unlocked a new item.
Pick up any 3 of the following items/trinkets in a single run: 9 Volt, The Battery, Car Battery, AAA Battery, Watch Battery
367
PS4 358
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It's the Key

Unlocked a new item.
Defeat The Lamb without taking hearts, coins, and bombs through an entire run
327
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Mama's Boy

Beat womb without taking damage.
Beat chapter 4 without taking damage
40
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Rubber Cement

Unlocked a new item.
Defeat Mom's Heart 2 times
150
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Rage Baby

Unlocked a new co-player baby.
Defeat Mega Satan as Samson
211
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Locust of Death

Unlocked a new item.
Defeat The Lamb as Apollyon
313
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Solar System

Unlocked Challenge #6.
Defeat Mom's Heart 3 times
159
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Mega

Unlocked...
Defeat Mega Satan as every character
276
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The Necropolis

Alt stage to the depths.
Beat all The Depths bosses (not restricted to beating bosses in the Depths)
88
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Something wicked this way comes+!

Unlocked even more bosses!
Defeat ??? as 6 different characters
347
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