Binding of Isaac WikiExploreChallengesAchievementsItemsCharacters
Binding of Isaac Wiki Binding of Isaac Wiki ChallengesAchievementsItemsCharacters
Binding of Isaac Wiki
??? Challenges
Binding of Isaac WikiExploreChallengesAchievementsItemsCharacters
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DLC Required
Featured
Hearts
Treasure Room
Shop
Goal

??? Challenges

Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.

Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks

BRAINS!

Order
27
Featured
???
Hearts (with Amounts)
3 Soul Hearts, Blindfolded
Conditions
3 Bob's Brain, Thunder Thighs
Goal
???
Unlocks
Stud Finder
Read More

Blue Bomber

Order
23
Featured
???
Hearts (with Amounts)
3 Soul Hearts, Blindfolded
Conditions
Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega
Goal
Satan
Unlocks
Gold Bomb
Read More
DLC Required
AfterbirthAfterbirth+None
Featured
???EveIsaacJudasLazarusMagdalene
Hearts
Black HeartsBlindfoldedEmpty HeartsRed HeartRed HeartsSoul Hearts
Treasure Room
NoYes
Shop
NoYes
Goal
???IsaacIt LivesMega SatanMomMom's HeartSatanThe Basement/The Cellar/Burning Basement I
Binding of Isaac Wiki Binding of Isaac Wiki



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