Definition of Unlocks
Unlocks
Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks
1
3 Red Hearts
Curse of Darkness, Curse of the Unknown
Rune of Hagalaz
2
3 Red Hearts
Number One, E Coli, Butt Bombs, Flush!, Petrified Poop
Rune of Jera
9
3 Red Hearts
Dr. Fetus, Remote Detonator, Match Stick
Chaos Card
22
3 Red Hearts
Get out of Jail Free Card
23
3 Soul Hearts, Blindfolded
Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega
Gold Bomb
6
3 Red Hearts, Blindfolded
Distant Admiration, Forever Alone, Halo of Flies, Transcendence
Rune of Perthro
18
3 Red Hearts
Technology .5
33
3 Red Hearts
Friendly Ball, Mom's Eyeshadow
Charged Key
29
1 Red Heart
The Book of Belial, Chocolate Milk
Kidney Stone
27
3 Soul Hearts, Blindfolded
3 Bob's Brain, Thunder Thighs
Stud Finder
25
1 Red Heart, 11 Empty Hearts
Charm of the Vampire
2 new pills
30
3 Red Hearts, Blindfolded
Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny
Blank Rune
10
4 Red Hearts
Blue Map, The Compass, Raw Liver, Treasure Map, Yum Heart , Child's Heart, Curse of the Cursed
Credit Card
17
3 Red Hearts
Anti-Gravity, Strange Attractor, The Mulligan, Spider Baby, Tick
Death's Touch
31
3 Red Hearts
8-10 random items
Laz Bleeds More!
11
1 Red Heart
Epic Fetus, Loki's Horns
Rules Card
13
3 Red Hearts, Blindfolded
9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro
Burnt Penny
32
3 Red Hearts
Maggy Now Holds a Pill!
28
3 Red Hearts
3 Dollar Bill, Rainbow Baby, Rainbow Worm
D8
12
3 Red Hearts
9 Volt, Habit, Lemon Mishap, 1 Lemon Party pill
Card Against Humanity