Binding of Isaac Wiki
Isaac Challenges
Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks
33
3 Red Hearts
Friendly Ball, Mom's Eyeshadow
Charged Key
29
1 Red Heart
The Book of Belial, Chocolate Milk
Kidney Stone
24
3 Red Hearts
Money = Power, Sack of Pennies, 50 coins
2 new pills
19
3 Red Hearts, Blindfolded
BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy
Epic Fetus
7
3 Red Hearts
Ipecac, Mr. Mega, My Reflection, 1 random Pill
Suicide King
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matches