It Lives Challenges


Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.

Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks

The Guardian

30
3 Red Hearts, Blindfolded
Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny
Blank Rune
Read More

Solar System

6
3 Red Hearts, Blindfolded
Distant Admiration, Forever Alone, Halo of Flies, Transcendence
Rune of Perthro
Read More
Copyright © 2019 BindingOfIsaacWiki.com and . All Rights Reserved.

All content on this website ("the Site") is the property of . The collection and assembly of content on this Site are the exclusive property of and are protected by copyright and other intellectual property laws. This website is not affiliated with The Binding of Isaac or Edmund McMillen. All copyrights reserved to their respective owners. We do not assert any claim of copyright for The BInding of Isaac. We are a fan site.