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Binding of Isaac Wiki Binding of Isaac Wiki ChallengesAchievementsItemsCharacters
Binding of Isaac Wiki
Mega Satan Challenges
Binding of Isaac WikiExploreChallengesAchievementsItemsCharacters
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DLC Required
Featured
Hearts
Treasure Room
Shop
Goal

Mega Satan Challenges

Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.

Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks

Ultra Hard

Order
34
Featured
Isaac
Hearts (with Amounts)
3 Red Hearts
Conditions
Key Piece 1, Key Piece 2, Curse of the Labyrinth, Curse of the Blind, Curse of the Lost, Curse of the Maze
Goal
Mega Satan
Unlocks
Samson Feels Healthy!
Read More

I RULE!

Order
26
Featured
Isaac
Hearts (with Amounts)
3 Red Hearts
Conditions
The Boomerang, Key Piece 1, Key Piece 2, The Ladder, Mom's Knife, Trinity Shield
Goal
Mega Satan
Unlocks
Poker Chip
Read More
DLC Required
AfterbirthAfterbirth+None
Featured
???EveIsaacJudasLazarusMagdalene
Hearts
Black HeartsBlindfoldedEmpty HeartsRed HeartRed HeartsSoul Hearts
Treasure Room
NoYes
Shop
NoYes
Goal
???IsaacIt LivesMega SatanMomMom's HeartSatanThe Basement/The Cellar/Burning Basement I
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