Mom Challenges
Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks
32
3 Red Hearts
Maggy Now Holds a Pill!
30
3 Red Hearts, Blindfolded
Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny
Blank Rune
28
3 Red Hearts
3 Dollar Bill, Rainbow Baby, Rainbow Worm
D8
25
1 Red Heart, 11 Empty Hearts
Charm of the Vampire
2 new pills
22
3 Red Hearts
Get out of Jail Free Card
21
3 Red Hearts
Gold Heart
20
3 Red Hearts
Rune of Berkano
18
3 Red Hearts
Technology .5
17
3 Red Hearts
Anti-Gravity, Strange Attractor, The Mulligan, Spider Baby, Tick
Death's Touch
16
3 Red Hearts
Spoon Bender, Technology, Technology 2
Robo-Baby 2.0
15
3 Red Hearts
Cupid's Arrow, My Reflection, Polyphemus
Swallowed Penny
14
3 Red Hearts
9 Volt, The Battery, Deck of Cards, Starter Deck, 2 random tarot cards
SMB Super Fan
13
3 Red Hearts, Blindfolded
9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro
Burnt Penny
12
3 Red Hearts
9 Volt, Habit, Lemon Mishap, 1 Lemon Party pill
Card Against Humanity
10
4 Red Hearts
Blue Map, The Compass, Raw Liver, Treasure Map, Yum Heart , Child's Heart, Curse of the Cursed
Credit Card
9
3 Red Hearts
Dr. Fetus, Remote Detonator, Match Stick
Chaos Card
8
3 Soul Hearts, 3 Black Hearts, Blindfolded
Guppy's Hair Ball, Guppy's Head, Guppy's Tail
Rune of Algiz
6
3 Red Hearts, Blindfolded
Distant Admiration, Forever Alone, Halo of Flies, Transcendence
Rune of Perthro
5
4 Red Hearts
Infamy, Bucket of Lard, Thunder Thighs, Yum Heart
Rune of Ansuz
3
3 Red Hearts
Tiny Planet, Soy Milk, The Small Rock, Iron Bar
Rune of Ehwaz
2
3 Red Hearts
Number One, E Coli, Butt Bombs, Flush!, Petrified Poop
Rune of Jera
1
3 Red Hearts
Curse of Darkness, Curse of the Unknown
Rune of Hagalaz
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