Binding of Isaac Wiki
Mom's Heart Challenges
Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks
32
3 Red Hearts
Maggy Now Holds a Pill!
30
3 Red Hearts, Blindfolded
Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny
Blank Rune
28
3 Red Hearts
3 Dollar Bill, Rainbow Baby, Rainbow Worm
D8
25
1 Red Heart, 11 Empty Hearts
Charm of the Vampire
2 new pills
22
3 Red Hearts
Get out of Jail Free Card
21
3 Red Hearts
Gold Heart
20
3 Red Hearts
Rune of Berkano
9
3 Red Hearts
Dr. Fetus, Remote Detonator, Match Stick
Chaos Card
6
3 Red Hearts, Blindfolded
Distant Admiration, Forever Alone, Halo of Flies, Transcendence
Rune of Perthro
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matches