Mom's Heart Challenges

Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.

Hearts (with Amounts)

The Guardian

3 Red Hearts, Blindfolded
Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny
Blank Rune
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Solar System

3 Red Hearts, Blindfolded
Distant Admiration, Forever Alone, Halo of Flies, Transcendence
Rune of Perthro
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