Binding of Isaac Wiki
Satan Challenges
Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks
34
3 Red Hearts
Key Piece 1, Key Piece 2, Curse of the Labyrinth, Curse of the Blind, Curse of the Lost, Curse of the Maze
Samson Feels Healthy!
26
3 Red Hearts
The Boomerang, Key Piece 1, Key Piece 2, The Ladder, Mom's Knife, Trinity Shield
Poker Chip
23
3 Soul Hearts, Blindfolded
Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega
Gold Bomb
11
1 Red Heart
Epic Fetus, Loki's Horns
Rules Card
4
2 Red Hearts
Pentagram, Dead Bird, Whore of Babylon, Razor Blade, Sacrificial Dagger, Dark Matter
Rune of Dagaz
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matches