Item: <3

Increases damage, but also increases the chance of champion enemies appearing.

Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.

Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.

Randomizes all passive items upon pickup and at the start of each succeeding floor.

+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.

Removed in Afterbirth: Automatically inflicts slow to all enemies in every room.
Added in Afterbirth: Upon taking damage, inflicts slow to all enemies for the current room.

Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.

Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.

Dagger orbits Isaac, dealing very high damage.

Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.

Isaac's head is removed from his body and floats around him. Increases Damage by 1 and grants -1 Tear Delay.

Tears up, adds 1 soul heart, and decreases Isaac's size.

Grants 2 soul hearts and modifies drops from Champion Monsters based on certain conditions.

After taking damage a certain amount of times, a permanent demonic familiar spawns.

The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.

Grants Isaac one red heart container and fully restores Isaac's health.

Grants 1 heart container and increases tears, but decreases shot speed.

Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360 degree tear firing radius. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone.

A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.

When taking damage, Isaac farts, causing poison damage to all enemies in range.