Item: 7 Seals
Grants one red heart container, restores 5 red hearts, and increases speed by 0.3.
A familiar that charges forward and deals touch damage to any enemies in its path.
Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
Tears fired from left eye do increased damage.
Whore of Babylon
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
Upon picking up a certain amount of health, spawn a permanent angelic familiar.
Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Increases range and shot speed, while adding 1 Black Heart.
Drops a random card or rune. Doubles the effects of cards and runes.
Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Adds a chance to reflect enemy shots. Grants one soul heart.
Dagger orbits Isaac, dealing very high damage.