Item: 9 Volt
Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or keyafter clearing a room.
Adds a chance to fire a gas cloud that damages nearby enemies.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Eye of Greed
Adds a chance to fire tears that temporarily stun enemies and turn them into gold. Any enemy killed while in this state will drop coins.
Grants an empty heart container. Increases damage, range and shot height while reducing speed.
Spawns a familiar that flies the room while firing, dealing double Isaac's tear damage to enemies that come in contact and retrieving pickups.
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
Grants charged tears that deal greater damage when fully charged.
Whore of Babylon
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Fliesdamaging enemies it passes through.
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.
Head of the Keeper
Isaac's tears become coins and now have a chance to drop pennies on the floor upon successfully hitting an enemy.