+1 luck. Spawns a fairy familiar that points out secret room entrances and tinted rocks.
Taking damage releases a ring of 10 high damage tears.
Tears are replaced with piercing white blasts of light.
Connects Isaac's tears with electricity that can damage enemies.
Drops a random card or rune. Doubles the effects of cards and runes.
Increases damage. Adds a chance to fire acidic tears which can destroy obstacles.
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Adds a chance to fire a booger which sticks to enemies and poisons them.
Shard of Glass
Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
Sack of Sacks
Spawns a sack familiar that has a chance to drop a sack upon clearing a room.
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Allows Isaac to carry two cards, pills, or any combination of both at the same time. Drops a random card or pill.
Upon entering a room with enemies in it, has a chance to spawn a random charmed enemy that persists across rooms.
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.
Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Adds a chance to reflect enemy shots. Grants one soul heart.
Grants one bone heart and spawns three red heart pickups.
Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.
Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Adds a chance to fire a gas cloud that damages nearby enemies.
Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Glyph of Balance
Grants 2 soul hearts and modifies drops from Champion Monsters based on certain conditions.
Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Adds a chance to shoot a fire that damages enemies and remains in place until it deals enough damage or the room is left.
Spawns a finger familiar that points at enemies, dealing constant damage.
Grants 7 bombs and allows bombs to be placed rapidly.
Eye of Greed
Adds a chance to fire tears that temporarily stun enemies and turn them into gold. Any enemy killed while in this state will drop coins.
Eye of Belial
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
An Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Increases damage and speed. Upon entering a room adjacent to a secret room, a howl sound effect will play.
Spawns a Mysterious Paper, increases tears, and grants a bone heart.
Spawns a cloud familiar that leaves a trail of tears that damages enemies. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Grants a reward if all enemies in a room are killed in the order they are marked.
While firing, Isaac gains a green aura that poisons nearby enemies.
Dark Prince's Crown
Increases range, tears, and shot speed when at exactly one red heart.
Creates a ring of light around Isaac that petrifies enemies in contact.
Dad's Lost Coin
Increases range by 1.5. Drops a lucky penny.
The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.