Item: Analog Stick
Spawns a familiar that drops random pills every 2 rooms cleared. Upon using a pill, all enemies in the room are poisoned.
Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Isaac can hold 2 cards at once and all pills are replaced by cards.
Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
Causes Isaac's activated item to activate twice on each use.
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Wanders about the room, occasionally spawning blue spiders.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Increases all stats and enlargens Isaac.
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.
Grants a familiar that transforms into another random familiar every 10 seconds.
Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.