Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Destroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Spawns a familiar that follows Isaac around and fires tears with random effects.
Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
A Lump of Coal
The more distance tears travel, the more damage they will do.
Magic 8 Ball
Increases Shot Speed, and drops a Tarot Card when picked up.
Cube of Meat
Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
8 Inch Nails
+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Replaces all red hearts with 6 empty bone hearts. Upon losing a bone heart, Isaac fires bones in 8 directions and permanently gains a tears up.
Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals.
Spawns 2 keys. Generates additional pickups from chests.
Upon entering a room with enemies in it, has a chance to spawn a random charmed enemy that persists across rooms.
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
Ball of Tar
Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.