Grants a reward if all enemies in a room are killed in the order they are marked.
Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Sets your key count to the maximum of 99.
Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Adds a chance to shoot a fire that damages enemies and remains in place until it deals enough damage or the room is left.
Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Gives a random chance for projectiles to fire in all 4 cardinal directions.
+5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.
Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knock back, poison, or charm all nearby enemies.
A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Increases damage and speed. Upon entering a room adjacent to a secret room, a howl sound effect will play.
Isaac's tears gain a random effect that changes every shot.
Adds a chance to reflect enemy shots. Grants one soul heart.
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.