Spawns a Mysterious Paper, increases tears, and grants a bone heart.
A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Grants 1 heart container and increases tears, but decreases shot speed.
Grants one Heart Container and gives 2 Soul Hearts.
Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
-1 Tear Delay, adds knock-back shots and increases tear size.
Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
Automatically negates first taken damage in every room.
Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
???'s Only Friend
Summons a big attack fly that can be controlled with the shooting direction-keys.
Buddy in a Box
Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.
Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
An orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an eternal heart.
A bag that follows Isaac and drops a random rune every 3 rooms.
Increases Damage by 1 and adds a chance to shoot fear tears.
Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Increases tears by 0.4, and spawns 2 Soul Hearts pickups.