A familiar that charges forward and deals touch damage to any enemies in its path.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Gives Isaac's tears a boomerang effect, and increases range and shot speed.
Key Piece 1
Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Spirit of the Night
Grants spectral tears and flight.
Grants 1 heart container and increases tears, but decreases shot speed.
Cube of Meat
Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
Upon dying, resurrect as Revived Lazarus with one heart container and Anemic item.
A familiar that drops a Little Battery every 4 rooms. Has a small chance to freeze all enemies in the room when hit.
Increases the size of blue spiders and Blue Flies and doubles the amount of damage they deal.
Doubles damage, halves tears stat, and greatly reduces shot speed.
Spawns a familiar that follows Isaac around and fires tears with random effects.
Adds 3 black hearts and increases Damage by 1.
Increases Shot Speed and damage.
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Isaac can hold 2 cards at once and all pills are replaced by cards.
Tears up, adds 1 soul heart, and decreases Isaac's size.
Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.