Item: Ball of Bandages
Follows Isaac and automatically fires at enemies in its reach.
Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Key Piece 2
Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.
Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.
Contract From Below
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
Wanders about the room, occasionally spawning blue spiders.
Reveals and opens all Secret Room and Super Secret Room entrances.
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Spawns a Mysterious Paper, increases tears, and grants a bone heart.
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Magic 8 Ball
Increases Shot Speed, and drops a Tarot Card when picked up.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.