Item: Best Bud
Spawns 2 keys. Generates additional pickups from chests.
Spider enemies no longer target or deal contact damage to Isaac.
Key Piece 2
Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Grants a reward if all enemies in a room are killed in the order they are marked.
Creates a ring of light around Isaac that petrifies enemies in contact.
Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Grants an empty heart container. Increases damage, range and shot height while reducing speed.
Gives one heart container and doubles the healing provided by red hearts.
There will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear.
Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Isaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.
Adds a chance to fire a gas cloud that damages nearby enemies.
If the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.
Greatly increases the chance to find sacks.
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Chance to block projectiles coming from any direction.
Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.