Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Upon entering a room with enemies in it, has a chance to spawn a random charmed enemy that persists across rooms.
Inflicts poison to enemies who make contact with Isaac. Speed down.
Reveals all rooms for every floor. However, it does not reveal icons or secret rooms.
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Upon picking up a certain amount of health, spawn a permanent angelic familiar.
Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
Grants a heart container for every 25 coins Isaac has.
Connects Isaac's tears with electricity that can damage enemies.
Increases damage, but also increases the chance of champion enemies appearing.
Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Increases Damage by 1 and adds a chance to shoot fear tears.
Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.