Grants four soul hearts and fully restores Isaac's red health.
Increases speed by +0.2 and grants piercing tears.
Tears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired.
Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.
Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Adds a chance to shoot fear tears and decreases tear delay by 1.
Whore of Babylon
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Increases damage, and adds 1 heart container.
Increases Shot Speed and damage.
Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
1-3 Blue flies randomly spawn every time Isaac gets hit.
Increases speed by 0.6, range by 5.25, and tear height by 0.5.
All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
The Small Rock
Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.