Item: Big Chubby
Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.
Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.
Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny.
When hit, summons a white attack fly similar to Distant Admiration for the current room.
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
Shows secret and super secret room locations on the map.
Lord of the Pit
Grants flight and increases speed.
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Head of the Keeper
Isaac's tears become coins and now have a chance to drop pennies on the floor upon successfully hitting an enemy.
+5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.
Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.
One of two parts necessary to create Mom's Shovel.
Pay to Play
This item turns all doors that require a key into doors which need a coin to enter instead. This affects shops, item rooms, libraries and other key doors.
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Drops a random card or rune. Doubles the effects of cards and runes.
Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.