Item: Black Candle
Adds a chance to shoot a fire that damages enemies and remains in place until it deals enough damage or the room is left.
+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
Grants Isaac one red heart container and fully restores Isaac's health.
Inflicts poison to enemies who make contact with Isaac. Speed down.
All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Gives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes.
8 Inch Nails
+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
Mom's Coin Purse
Spawns 4 random pills around Isaac.
Spawns 2 keys. Generates additional pickups from chests.
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Grants one red heart container, restores 5 red hearts, and increases speed by 0.3.
Summons a familiar that copies the tears of Isaac's other familiars.
Whore of Babylon
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or keyafter clearing a room.
Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
Lord of the Pit
Grants flight and increases speed.