Item: Black Lotus
A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
The Small Rock
Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
Increases speed by 0.3 and shot speed by 20%.
Tears shrink and do much less damage, but fire in very rapid succession.
A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
Upon entering a room with enemies in it, has a chance to spawn a random charmed enemy that persists across rooms.
If the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.
The Ludovico Technique
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Enemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
Grants a reward if all enemies in a room are killed in the order they are marked.
Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.
Increases range and shot height.
Increases speed by 0.6, range by 5.25, and tear height by 0.5.
A familiar that damages enemies by chasing them as well as inducing the fear effect.
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.