Item: Blank Card
When used, converts two soul hearts into a heart container.
Throws a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots.
Telepathy for Dummies
Upon activation, grants homing tears for the current room.
Upon use, spawns certain pickups or itemsdepending on the floor it is used on. Single-use.
Freezes all enemies until a fire button is pressed.
If the box is empty, picks up all items and pickups in a room and stores them. If the box is not empty, places all stored items and pickups in the current room.
Bob's Rotten Head
Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.
Kills all enemies in the room, then kills Isaac three seconds later.
Grants a random item effect for the current room.
Mom's Bottle of Pills
Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.
Spawns a stationary fly familiar that fires tears at nearby enemies.
Consumes Isaac's currently held trinket and applies its effect permanently.
Book of the Dead
Upon use, spawns a charmed Bony or an orbital bone for each enemy killed in the current room.
How to Jump
Gives Isaac the ability to jump (over gaps, spikes, etc.).
Damages all enemies in the room, but deals a heart of damage to Isaac with each use.
Removes one red heart container in exchange for gaining 3 Soul Hearts.
Creates a small yellow pool of creep, which damages enemies that cross it.