Eye of Belial
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up.
Grants a random Harbinger familiar that changes every 10 seconds.
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Zodiac will give Isaac a random zodiac item effect that changes after every floor.
Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Greatly increases the chance to find sacks.
Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Reveals all special rooms (except secret rooms of any kind).
Taking damage releases a ring of 10 high damage tears.
Gives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes.
Increases damage by 0.5, and multiplies it by 1.5x.
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies (Similar to The Common Cold item). Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick). Enemies that were poisoned have a chance to drop a black heart when killed.