Item: Bloody Lust
Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.
Crown of Light
Gives Isaac a crown that glows blue when active, and turns gray when inactive. While Isaac has no empty red heart containers, Isaac's tears are replaced with blue diamond tears that deal double damage. Regardless of health, the crown will deactivate for the current room when Isaac takes damage.
Grants four soul hearts and fully restores Isaac's red health.
Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Gives a random chance for projectiles to fire in all 4 cardinal directions.
Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.
Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Converts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup.
Ball of Tar
Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Increases Luck by 1, grants 1 Soul Heart and spawns 2 Keys.
Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.
Activated Items can be "overcharged" to allow for an additional use.
Spawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket.
Head of the Keeper
Isaac's tears become coins and now have a chance to drop pennies on the floor upon successfully hitting an enemy.
Adds a chance to shoot concussive tears, causing enemies to walk around randomly.