Item: Bob's Curse
Grants 1 heart container and increases tears, but decreases shot speed.
Reveals all rooms for every floor. However, it does not reveal icons or secret rooms.
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Grants a reward if all enemies in a room are killed in the order they are marked.
Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Increases range and shot height.
Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U A Wizard?pill. Isaac's tears also travel above all obstacles.
Grants the player one red heart container, one soul heart, and one black heart.
Increases damage by 1 and speed by 0.4.
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Upon picking up a certain amount of health, spawn a permanent angelic familiar.
While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.