Item: Bomb Bag
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
A familiar that follows Isaac around shooting blood tears.
Drops a random card or rune. Doubles the effects of cards and runes.
A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
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Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
An Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Increases Shot Speed and damage.
+5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.
8 Inch Nails
+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Isaac becomes camouflaged at the beginning of each room. Enemies will not attack Isaac until he starts firing tears.
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
The Common Cold
Adds a chance to shoot poison tears, dealing damage over time when inflicted.