Item: Book of Secrets
Upon use, deals one heart of damage to Isaac and grants +1.2 damage for the current room.
My Little Unicorn
Upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
Summons a controllable ghost that can perform various tasks depending on what it targets.
For 1 coin, damages all enemies in the room.
Breath of Life
Grants a brief moment of invincibility when the charge bar hits zero. If spacebar is held for an additional second after hitting zero, Isaac will take damage.
Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack the Sky.
Opens all doors in the current room when activated, including doors which require a key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and the Dark Room.
Upon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine.
Dead Sea Scrolls
Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Forget Me Now
When activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Disappears after use.
Teleports you to a random room on the level.
Grants a random dice item that changes each use.
Creates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius.
Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.
Summons a random familiar for the current room. Can summon familiars not yet unlocked.
Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.
Bombs you place explode only when you use this item. Gives 5 bombs.