Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
1-3 Blue flies randomly spawn every time Isaac gets hit.
When Isaac is hit, 1 point of an item's charge is filled.
Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
While firing, Isaac gains a green aura that poisons nearby enemies.
Adds 3 black hearts and increases Damage by 1.
Increases damage by 1 and speed by 0.4.
Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
Replaces tears with a piercing laser with unlimited range.
Spawns allied blue spiders from killed enemies.
Crown of Light
Gives Isaac a crown that glows blue when active, and turns gray when inactive. While Isaac has no empty red heart containers, Isaac's tears are replaced with blue diamond tears that deal double damage. Regardless of health, the crown will deactivate for the current room when Isaac takes damage.
Allows Isaac to carry two cards, pills, or any combination of both at the same time. Drops a random card or pill.
Ball of Tar
Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Spawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with.
A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.