Item: Box of Friends
Transforms Isaac into another random character.
Breath of Life
Grants a brief moment of invincibility when the charge bar hits zero. If spacebar is held for an additional second after hitting zero, Isaac will take damage.
Throws a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots.
When used, has a 50% chance to drop one random type of coin (penny, nickel, or dime).
Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.
Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.
When used, reduces Isaac's health to half a heart (including soul and black hearts) and fires one large piercing spectral tear that does a lot of damage. The damage done by Glass Cannon scales with Isaac's damage (at base damage it does 45 damage).
How to Jump
Gives Isaac the ability to jump (over gaps, spikes, etc.).
My Little Unicorn
Upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
Glowing Hour Glass
When used, this item will rewind time, put Isaac back in the previous room, and undo anything that happened in the current room. Any health, pickups, or items gained or lost will be reset back to the previous state.
When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.
Adds one soul heart and allows the breaking of rocksand damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing.
Box of Friends
Upon use, duplicates all of Isaac's familiars for the current room.
Telepathy for Dummies
Upon activation, grants homing tears for the current room.
When at full health, up to 4 extra hearts can be stored in the jar.
Can be used to place an orange portal and a blue portal. Upon entering a portal, Isaac is teleported to the other portal.
When used, converts two soul hearts into a heart container.