Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.
Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up.
Increases damage as Isaac receives damage. Damage increase stays for the whole floor.
Each time Isaac kills an enemy, Isaac's damage increases for the current room.
Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.
Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Grants one soul heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears.
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
Gives 5 bombs and grants all bombs poison effect.
Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.
Tears start out massive with high damage, and then shrink down and become weaker over a short range.