Item: Brittle Bones
Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Causes Isaac's activated item to activate twice on each use.
After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
Increases damage, and adds 1 heart container.
Shard of Glass
Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Gives 5 bombs and grants all bombs poison effect.
Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.