Item: Broken Watch
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
A trail of blue creep is left behind Isaac, which damages enemies.
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Grants a familiar that transforms into another random familiar every 10 seconds.
Grants the player one red heart container, one soul heart, and one black heart.
Gives one heart container and doubles the healing provided by red hearts.
Two items spawn in every Treasure Room. Only one can be taken; the other will disappear.
Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up.
Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
Spawns a familiar that follows Isaac around and fires spectral tears.
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Spawns an orbiting eye familiar that fires tears every 2 seconds.
Grants Isaac 1 Black Heart and 3 bombs. Can also give troll bombs.
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.