Item: Brother Bobby

If the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.

A familiar that follows Isaac around shooting blood tears.

Gives one heart container and doubles the healing provided by red hearts.

Each time Isaac kills an enemy, Isaac's damage increases for the current room.

Increases damage based on how many empty heart containers Isaac has.

Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.

Randomizes all passive items upon pickup and at the start of each succeeding floor.

Adds 3 black hearts and increases Damage by 1.

Increases damage by 1 and range by 5 for tears fired from the left eye.

Grants charged tears that deal greater damage when fully charged.

Reveals type of adjacent rooms, including location for secret rooms and super secret rooms.

Grants Isaac one red heart container and fully restores Isaac's health.

Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.

A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knock back, poison, or charm all nearby enemies.

Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.

Adds a chance to shoot fear tears and decreases tear delay by 1.

Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.

A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.

Grants a heart container for every 25 coins Isaac has.

Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.