Item: Buddy in a Box
A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Spawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with.
Spawns a beggar familiar which floats around the room and picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo chases enemies slowly, dealing contact damage.
Grants a reward if all enemies in a room are killed in the order they are marked.
Adds one heart container and drops a random trinket.
Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Increases speed by 0.3 and shot speed by 20%.
Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals.
Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
A familiar that follows Isaac around shooting blood tears.
A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
Gives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes.
Head of the Keeper
Isaac's tears become coins and now have a chance to drop pennies on the floor upon successfully hitting an enemy.
Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.