Grants charged tears that deal greater damage when fully charged.
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Adds one heart container and drops a random trinket.
The Small Rock
Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
The Inner Eye
Grants triple shot but decreases tears.
Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.
Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range.
A Lump of Coal
The more distance tears travel, the more damage they will do.
Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Blood of the Martyr
Increases Damage by 1, and turns Isaac's tears into blood tears.
Ball of Bandages
Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Increases damage based on how many empty heart containers Isaac has.
Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U A Wizard?pill. Isaac's tears also travel above all obstacles.