Spawns a blue spider or fly. Turns pickups in the room into blue spiders or flies.
Upon activation, Isaac gains a black heart.
We Need to Go Deeper!
Creates a trapdoor to go to the next floor. If used in The Womb, it will create a trapdoor to Sheol, even if the player hasn't unlocked it.
Creates a small yellow pool of creep, which damages enemies that cross it.
Grants a random dice item that changes each use.
The Book of Sin
Spawns a random pickup, pill, card, or trinket.
Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.
Jar of Flies
Every time Isaac kills an enemy, a fly will be added to the jar, up to a maximum of 20. Using the Jar of Flies will release all the flies that are currently in the jar as friendly blue flies that will damage enemies.
Grants a random item effect for the current room.
Sets a big red target on the ground (similar to the Epic Fetus item) which can be controlled with tear controls. After 6 seconds or by pressing space again, a huge explosive missile hits it, which damages all enemies caught in its blast radius.
Box of Friends
Upon use, duplicates all of Isaac's familiars for the current room.
Consumes Isaac's currently held trinket and applies its effect permanently.
Isaac holds the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items.
Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.
Upon use, turns Isaac's head into a stationary familiar for the current room which fires normal tears that deal 3.5 damage.