Item: Compound Fracture
Spawns a familiar that follows Isaac around and fires homing tears.
+0.3 tears up. Allows Isaac to fire tears diagonally.
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range.
An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
The Small Rock
Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
Spawns a familiar that flies the room while firing, dealing double Isaac's tear damage to enemies that come in contact and retrieving pickups.
Curse of the Tower
Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
Upon picking up a certain amount of health, spawn a permanent angelic familiar.
Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
Crown of Light
Gives Isaac a crown that glows blue when active, and turns gray when inactive. While Isaac has no empty red heart containers, Isaac's tears are replaced with blue diamond tears that deal double damage. Regardless of health, the crown will deactivate for the current room when Isaac takes damage.
Grants Isaac one full red heart container.
Isaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
When hit, summons a white attack fly similar to Distant Admiration for the current room.
Grants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.
Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.
Mom's Coin Purse
Spawns 4 random pills around Isaac.
Spawns a beggar familiar which floats around the room and picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo chases enemies slowly, dealing contact damage.