Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Reveals all rooms for every floor. However, it does not reveal icons or secret rooms.
Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
Spirit of the Night
Grants spectral tears and flight.
When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.
Spawns a blue attack fly that orbits a long distance from Isaac.
Increases Damage by 1 and adds a chance to shoot fear tears.
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Upon entering a room with enemies in it, has a chance to spawn a random charmed enemy that persists across rooms.
Upon death, the player will respawn as ??? with 3 soul hearts.
Whore of Babylon
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.