Item: Crack Jacks
Adds a chance to reflect enemy shots. Grants one soul heart.
After taking damage a certain amount of times, a permanent demonic familiar spawns.
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Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.
Grants a reward if all enemies in a room are killed in the order they are marked.
Greatly increases the chance to find sacks.
Allows Isaac to hold 1 additional trinket.
Contract From Below
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Circle of Protection
Surrounds Isaac with a large white halo around him that pulsates. With each pulse, the halo deals contact damage to enemies equal to Isaac's damage. Each pulse also converts any enemy shots touching the ring into friendly purple homing tears.
Increases Damage and Speed, plus adds one Soul Heart.
Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Drops a random card or rune. Doubles the effects of cards and runes.
Tears are replaced with piercing white blasts of light.
Isaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.
Isaac becomes camouflaged at the beginning of each room. Enemies will not attack Isaac until he starts firing tears.
Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.