Item: Crack the Sky
Upon activation, enemies and their projectiles are slowed down for a short duration.
Duplicates all pickups and item pedestals in the room.
Bob's Rotten Head
Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
Throws a black hole on the ground which sucks in and damages enemies.
Removes one red heart container in exchange for gaining 3 Soul Hearts.
When used, Mom's Box will drop a random trinket on the ground. While held, increases luck by 1 and doubles the effects of trinkets.
Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.
Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies.
Spawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.
Consumes Isaac's currently held trinket and applies its effect permanently.
Upon use, petrifies all enemies in the current room for approximately 4 seconds.
Upon use, spawns a random item from the current room's item pool, with a chance to spawn A Lump of Coal or The Poop instead.
Grants a random dice item that changes each use.
Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
Rerolls the enemies in a room. Only rerolls enemies that are still alive (does not spawn new enemies).
When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing.