Item: Curse of the Tower
Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
Grants one soul heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears.
Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Spawns allied blue spiders from killed enemies.
Isaac can hold 2 pills at once and all cards are replaced by pills.
A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360 degree tear firing radius. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone.
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Grants a soul heart. Adds a chance to block enemy shots.
Grants Isaac 1 Black Heart and 3 bombs. Can also give troll bombs.
Gives Isaac 99 coins. Can be found multiple times in a single playthrough.
Grants 1 heart container and increases tears, but decreases shot speed.
All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
Enemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.