Grants a random item effect for the current room.
Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.
Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.
Spawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.
Book of Shadows
Upon use, creates a protective shield nullifying all types of damage for 10 seconds.
When used, copies the effect of the pill Isaac is currently holding without consuming it. Does not copy the effects of cards or runes.
When used, converts two soul hearts into a heart container.
Upon use, spawns a random item from the current room's item pool, with a chance to spawn A Lump of Coal or The Poop instead.
Isaac holds the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items.
Consumes Isaac's currently held trinket and applies its effect permanently.
Spawns a blue spider or fly. Turns pickups in the room into blue spiders or flies.
Damages all enemies and destroys all obstacles. The effect occurs every time a new room is entered for the rest of the floor. Opens doors to the floor's secret and super secret rooms.
Upon use, petrifies all enemies in the current room for approximately 4 seconds.
Throws a black hole on the ground which sucks in and damages enemies.
Box of Friends
Upon use, duplicates all of Isaac's familiars for the current room.
Head of Krampus
Fires a cross-patterned brimstone shot, just like The Fallen and Krampus shoot.
Book of Revelations
Adds 1 soul heart, increases the chance for a Devilor Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
When at full health, up to 4 extra hearts can be stored in the jar.