Item: Daddy Longlegs
Has a chance to drop a random pickup when Isaac takes damage.
Allows Isaac to carry two cards, pills, or any combination of both at the same time. Drops a random card or pill.
One of two parts necessary to create Mom's Shovel.
Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Curse of the Tower
Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
Reveals all special rooms (except secret rooms of any kind).
Tears up, adds 1 soul heart, and decreases Isaac's size.
Drops a random trinket. Grants a second trinket slot.
Shard of Glass
Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Upon death, the player will respawn as ??? with 3 soul hearts.
Grants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.
Once per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.
Automatically negates first taken damage in every room.
+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
Spawns a familiar that follows Isaac around and fires homing tears.