Item: Dad's Ring
All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
Grants one soul heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears.
Spawns a familiar that flies the room while firing, dealing double Isaac's tear damage to enemies that come in contact and retrieving pickups.
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
8 Inch Nails
+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
+1.7 tears, +0.3 speed, reduces damage.
A familiar that damages enemies by chasing them as well as inducing the fear effect.
Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
A trail of blue creep is left behind Isaac, which damages enemies.
Isaac's tears have a chance to stick to enemies and explode.
Replaces all red hearts with 6 empty bone hearts. Upon losing a bone heart, Isaac fires bones in 8 directions and permanently gains a tears up.
Spawns a Mysterious Paper, increases tears, and grants a bone heart.
Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.