Item: Dark Matter

Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.

Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.

A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.

Increases speed by 0.3 and shot speed by 20%.

Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.

Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.

Spawns a familiar that follows Isaac around and fires spectral tears.

Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.

+0.7 tears up. Grants a random item at the start of the next run.

Once per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.

Allows Isaac to hold 1 additional trinket.

+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.

Grants a random Harbinger familiar that changes every 10 seconds.

When Isaac is hit, 1 point of an item's charge is filled.

Causes shops to instantly restock their items when they are bought. Granted by default for every character in Greed Mode.

+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.

Allows Isaac to hold two active items.

Increases Luck by 1, grants 1 Soul Heart and spawns 2 Keys.

Increases speed by 0.3.

Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.