Throws a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots.
Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
Book of the Dead
Upon use, spawns a charmed Bony or an orbital bone for each enemy killed in the current room.
Has the same effect as the card or rune currently held by Isaac.
Isaac releases bad gas, poisoning any enemy in close vicinity.
When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.
Rerolls the enemies in a room. Only rerolls enemies that are still alive (does not spawn new enemies).
Upon use, inflicts fear to all enemies in the room for 5 seconds.
Damages all enemies and destroys all obstacles. The effect occurs every time a new room is entered for the rest of the floor. Opens doors to the floor's secret and super secret rooms.
Adds one soul heart and allows the breaking of rocksand damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
Upon use, spawns a random item from the current room's item pool, with a chance to spawn A Lump of Coal or The Poop instead.
Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.
Book of Secrets
Upon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.
Upon activation, 1 coin will be consumed, and a random pickup may drop, similar to the slot machine.
The Book of Sin
Spawns a random pickup, pill, card, or trinket.
If the box is empty, picks up all items and pickups in a room and stores them. If the box is not empty, places all stored items and pickups in the current room.